Case analysis   Prostatitis rat model

The most common type of the prostatitis syndromes is chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CNP/CPPS), which is considered as one of the major urological problems in men younger than 50 years. Its prevalence has been estimated range from 2 to 10%CNP, as the most common and debilitating prostatitis syndrome, is a major international health problem in men which both makes urinary symptoms and also reduces quality of life.

We induced CNP through intraprostatic injection of 1% carrageenan in rat. The advantages of this model are the protocol of the experiment is quite simple, and carrageenan-induced pain is similar to the CNP/CPPS patients, the infiltration of inflammatory cell and COX2 expression can be induced by intraprostatic carrageenan injection. Subsequently, prostaglandins derived from COX-2, particularly prostaglandin E2 were main factors responsible for the classic triad of inflammation symptoms (pain, fever and swelling).

Caracteristics

Increased white blood cell content in blood routine and urine routine, the prostate weight and body weight in CNP-model increased, Prostatic index(PI)= weight of prostrate /bodyweight increased. severe diffuse chronic inflammation characterized by the moderate leucocyte infiltration, marked glandular epithelium hyperplasia and reducing the volume of the lumen were observed in the CNP model.

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